Endocrine Abstracts

Familial hyperaldosteronism type I (FH-I) is a rare subset of primary aldosteronism (PA) with an autosomal domintant pattern of inheritance. The molecular basis was determined to be from the unequal crossing over of the 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes, resulting in a chimeric gene duplication. This in turn leads to the ectopic synthesis of aldosterone in the zona fasciculata of the adrenal glands under the regulation of adrenocorticotrop...

Background: Oral levothyroxine (LT4) is usually an effective treatment for hypothyroidism. However, timing of meals, concurrent medications and gastrointestinal diseases causing malabsorption may impair absorption of oral LT4. We present a patient with Hashimoto’s thyroiditis on LT4 replacement through a gastrostomy tube causing the problem of erratic thyroid function test (TFT) results, successfully managed through the use of once-weekly intramuscular LT4 injection.<...